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The HIGHLAND COUNTY School Board is committed to nondiscrimination with regard to sex, sexual orientation, gender, gender identity, race, color, national origin, disability, religion, ancestry, age, marital status, pregnancy, childbirth or related medical conditions, military status, genetic information or any other characteristic protected by law. This commitment prevails in all of its policies and practices concerning staff, students, educational programs and services, and individuals and entities with whom the Board does business. Highland County School Board is an equal opportunity employer.


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The Big Spring School District is an equal opportunity education institution and will not discriminate on the basis of race, color, national origin, sex, age, religion, and disability in its activities, programs, or employment practices as required by Title VI, Title IX, and Section 504.

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Figure 1. Mechanisms of sex-specific differences in outcomes following prenatal opioid exposure begins before birth and occurs due to complex interplay of many factors including, but not limited to: (1) sex-specific regulation of genetic and epigenetic changes influenced by maternal, placental and fetal factors (2) sex-specific influence on growth and neurodevelopment (3) sex-specific differences in immune and endocrine function. Figure created with .

Table 1. Summary of sex-specific alterations noted in endogenous and exogenous opioid functions.

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